<p>Atypical musculoskeletal manifestations of gout in hyperuricemia patients</p>

Introduction: hyperuricemia and gout.

The pathophysiology of gout is well understood, and effective treatments for acute gout and hyperuricemia leading to gout are widely available. Nonetheless, many patients suffer from severe tophaceous gouty arthritis, adverse effects of medications for gout, and inadequate treatment of hyperuricemia. The incidence of gout is rising in both men and women. The diagnosis and treatment of gout are ...

Gout. Novel therapies for treatment of gout and hyperuricemia

In the past few decades, gout has increased not only in prevalence, but also in clinical complexity, the latter accentuated in part by a dearth of novel advances in treatments for hyperuricemia and gouty arthritis. Fortunately, recent research reviewed here, much of it founded on elegant translational studies of the past decade, highlights how gout can be better managed with cost-effective, wel...

Management of hyperuricemia and gout in CKD.

A 55-year-old man with history of kidney transplantation years ago because of diabetic nephropathy has severe ophaceous gout. He has been unable to tolerate treatment ith allopurinol because of worsening skin rashes. His last erum creatinine level was 2.3 mg/dL (203.3 mol/L). urrent medications include tacrolimus, mycophenolate ofetil, and prednisone at a dose of 20 mg/d orally. He resents to t...

Musculoskeletal ultrasonography in gout.

Gout is a frequent inflammatory disease induced by the deposition of monosodium urate crystals in joints and extra-articular tissues. The natural history of the disease includes four different phases: asymptomatic hyperuricemia, acute attacks, intercritical phase, and chronic tophaceous gout. Imaging techniques have several applications in the diagnosis, clinical monitoring and management of th...

Gout and Hyperuricemia in Chronic Kidney Disease